SBI-0637142
Names
[ CAS No. ]:
1612927-67-9
[ Name ]:
SBI-0637142
Biological Activity
[Description]:
SBI-0637142 is a potent Smac mimetic that preferentially targets BIRC2, latency-reversing agent (LRA), specifically and potently promote HIV-1 latency reversal activity.SBI-0637142 modestly induced HIV-1 latency ex vivo in CD4+ T cells from ART-suppressed aviremic HIV-infected patients as a single agent, showed robust activity when administered in combination with the HDACi panobinostat.SBI-0637142's latency reversal activity is dependent on the NIK-dependent NF-κB signaling.
[References]
1. Pache L, et al. Cell Host Microbe. 2015;18:345-353. 2. Lars Pache, et al. Cell Rep Med. 2020 Jun 23;1(3):100037.
Chemical & Physical Properties
[ Molecular Formula ]:
C25H36N4O3S
[ Molecular Weight ]:
472.648
Related Compounds
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.