Amotosalen hydrochloride

Names

[ Name ]:
Amotosalen hydrochloride

[Synonym ]:
Amotosalen hydrochloride (USAN)
Amotosalen HCl
S-59
7H-Furo(3,2-g)(1)benzopyran-7-one,3-((2-aminoethoxy)methyl)-2,5,9-trimethyl-,hydrochloride
Amotosalen hydrochloride
4'(4-amino-2-oxa)butyl-4,5',8-trimethylpsoralen Hydrochloride

Biological Activity

[Description]:

Amotosalen hydrochloride (S-59) is a light-activated, DNA-, RNA-crosslinking psoralen compound, which is used to neutralise pathogens[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

When activated by light, Amotosalen binds to the nucleic acid of the pathogen and prevents replication. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells[1].

[References]

[1]. Amotosalen: Allogeneic Cellular Immunotherapies system, INTERCEPT Plasma System, INTERCEPT Platelet System, S 59. BioDrugs. 2003;17(1):66-8.

Chemical & Physical Properties

[ Boiling Point ]:
488.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₂₁Cl₂NO₄

[ Molecular Weight ]:
337.79800

[ Flash Point ]:
249.4ºC

[ Exact Mass ]:
337.10800

[ PSA ]:
78.60000

[ LogP ]:
4.44200

[ Vapour Pressure ]:
1.06E-09mmHg at 25°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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