MNKI-8e
Names
[ CAS No. ]:
1610886-04-8
[ Name ]:
MNKI-8e
Biological Activity
[Description]:
MNKI-8e (MNK inhibitor 8e) is a potent, selective MNK inhibitor that inhibits Mnk2 with Ki of 0.37 uM, displays >34-fold and 4-fold over CDK2 (Ki>10 uM) and CDK9 (Ki=1.66 uM); potently inhibits leukemia cells with GI50 of 1.23-7.36 uM (MV4-11 GI50=1.32 uM and KG-1 GI50=1.23 uM); blocks phosphorylation of eIF4E, downregulates anti-apoptotic protein Mcl-1 and induces apoptosis in AML cells; suppresses the Ara-C-induced MAPK activity and enhances apoptosis in MV4-11 cells.
[References]
References 1. Diab S, et al. ChemMedChem. 2014 May;9(5):962-72. 2. Li P, et al. Oncotarget. 2016 Aug 30;7(35):56811-56825. View Related Products by Target MNK
Chemical & Physical Properties
[ Molecular Formula ]:
C17H18N4O3S
[ Molecular Weight ]:
358.416
Related Compounds
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