CFI-401980

Names

[ Name ]:
CFI-401980

Biological Activity

[Description]:

CFI-401980 is a potent, selective, novel class TTK (Tyrosine Threonine Kinase) inhibitor with Ki of 0.8 nM, HCT116 GI50 of 13 nM; shows exceptional kinase selectivity; demonstrate a strong anti-proliferative activity in a panel of human cancer cell lines (HCT116 GI50<15 nM) and good rodent pharmacokinetics (oral %F 97%).

[References]

References 1. Laufer R, et al. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3562-6. View Related Products by Target Monopolar Spindle 1 (Mps1/TTK)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₀N₆O₃

[ Molecular Weight ]:
498.587

Related Compounds

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