Mambalgin 1

Names

[ Name ]:
Mambalgin 1

Biological Activity

[Description]:

Mambalgin 1 is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 binds to closed/inactive channel. Mambalgin 1 is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 increases latency of withdrawal response in mouse tail-flick and paw-flick tests.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁₀H₄₈₁N₈₇O₁₀₀S₈

[ Molecular Weight ]:
7283.22

Related Compounds

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