AZD3264

Names

[ Name ]:
AZD3264

[Synonym ]:
2-(Carbamoylamino)-5-{4-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(3S)-3-pyrrolidinyloxy]phenyl}-3-thiophenecarboxamide
3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-[4-(3,5-dimethyl-4-isoxazolyl)-2-[(3S)-3-pyrrolidinyloxy]phenyl]-

Biological Activity

[Description]:

AZD3264 is a selective IkB-kinase IKK2 inhibitor.

[Related Catalog]:

Signaling Pathways >> NF-κB >> IKK

Research Areas >> Inflammation/Immunology

[Target]

IKK2

[In Vivo]

AZD3264 is a selective IkB-kinase IKK2 inhibitor, which is currently in preclinical development for the potential treatment of chronic pulmonary obstructive disorder (COPD) and asthma[1].

[References]

[1]. Andiappan Murugan, et al. Exploiting the Differential Reactivities of Halogen Atoms: Development of a Scalable Route to IKK2 Inhibitor AZD3264. Org Process Res Dev. 2014 Apr 29;18(5): 646-651.

[Related Small Molecules]

Resveratrol | MRT67307 | BMS-345541 | MLN120B | ACHP (Hydrochloride) | TPCA-1 | IKK-16 | IMD 0354 | LY2409881 | SC-514 | BI 605906 | Bay 65-1942 (hydrochloride) | TBK1/IKKε-IN-2 | PS-1145 | IKK-IN-1

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
614.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₃N₅O₄S

[ Molecular Weight ]:
441.503

[ Flash Point ]:
325.2±31.5 °C

[ Exact Mass ]:
441.147064

[ LogP ]:
2.08

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.653

[ Storage condition ]:
-20℃