Dap-NE

Names

[ CAS No. ]:
160800-82-8

[ Name ]:
Dap-NE

[Synonym ]:
2-Pyrrolidinepropanamide, N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]-β-methoxy-α-methyl-, (αR,βR,2S)-
(2R,3R)-N-[(1S,2R)-1-Hydroxy-1-phenyl-2-propanyl]-3-methoxy-2-methyl-3-[(2S)-2-pyrrolidinyl]propanamide

Biological Activity

[Description]:

Dap-NE is an intermediate reagent in the synthesis of the ADC toxin Monomethyl auristatin E (HY-15162)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Xiao Chao, et al. Monomethyl auristatin E single crystal as standard or reference substance and preparation method thereof. China, CN116768966 A. 2023-09-19.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
527.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H28N2O3

[ Molecular Weight ]:
320.427

[ Flash Point ]:
273.0±30.1 °C

[ Exact Mass ]:
320.209991

[ LogP ]:
1.06

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.531

Related Compounds