CFI-401870
Names
[ CAS No. ]:
1599460-95-3
[ Name ]:
CFI-401870
Biological Activity
[Description]:
A potent, selective, orally active Mps1 (TTK) inhibitor with IC50 of 3.1 nM; displays low off-target activity (>500-fold) and microsomal stability; inhibits HCT116 cell growth with GI50 of <0.1 uM, demonstrates in vivo tumor growth inhibition.
[References]
References 1. Liu Y, et al. J Med Chem. 2015 Apr 23;58(8):3366-92. View Related Products by Target Monopolar Spindle 1 (Mps1/TTK)
Chemical & Physical Properties
[ Molecular Formula ]:
C30H31N5O2
[ Molecular Weight ]:
493.611