CFI-401870

Names

[ Name ]:
CFI-401870

Biological Activity

[Description]:

A potent, selective, orally active Mps1 (TTK) inhibitor with IC50 of 3.1 nM; displays low off-target activity (>500-fold) and microsomal stability; inhibits HCT116 cell growth with GI50 of <0.1 uM, demonstrates in vivo tumor growth inhibition.

[References]

References 1. Liu Y, et al. J Med Chem. 2015 Apr 23;58(8):3366-92. View Related Products by Target Monopolar Spindle 1 (Mps1/TTK)

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₃₁N₅O₂

[ Molecular Weight ]:
493.611

Related Compounds

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