(S)-2-((S)-2-amino-3-methylbutanamido)-5-ureidopentanoic acid

Names

[ CAS No. ]:
159858-33-0

[ Name ]:
(S)-2-((S)-2-amino-3-methylbutanamido)-5-ureidopentanoic acid

Biological Activity

[Description]:

Val-Cit is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₂₂N₄O₄

[ Molecular Weight ]:
274.32

Related Compounds

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