ML401

Names

[ Name ]:
ML401

Biological Activity

[Description]:

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> EBI2/GPR183

[Target]

IC50: 1.03 nM (EBI2)[1]

[In Vitro]

ML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM)[1].

[In Vivo]

ML401 shows very good stability in both human plasma and mouse plasma[1].

[References]

[1]. Ardecky R, et al. Functional Antagonists of EBI-2. Probe Reports from the NIH Molecular Libraries Program [Internet].

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₀BrClN₂O

[ Molecular Weight ]:
419.74

Related Compounds

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