KDM5-C49

Names

[ Name ]:
KDM5-C49

[Synonym ]:
4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-
6OQJ5L847C
KDM5-C49
MFCD31539980
2-{[(2-{[2-(Dimethylamino)ethyl](ethyl)amino}-2-oxoethyl)amino]methyl}isonicotinic acid

Biological Activity

[Description]:

KDM5-C49 is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively; displays 25-100-fold selectivity over KDM6B, 2-30-fold selectivity over KDM4 family, but with less cell-permeablity.

[References]

References 1. Johansson C, et. Nat Chem Biol. 2016 Jul;12(7):539-45. 2. Horton JR, et al. Cell Chem Biol. 2016 Jul 21;23(7):769-81. View Related Products by Target Histone Demethylase

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
531.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₄N₄O₃

[ Molecular Weight ]:
308.376

[ Flash Point ]:
275.0±30.1 °C

[ Exact Mass ]:
308.184845

[ LogP ]:
-0.13

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.552

Related Compounds

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