[R-(R*,S*)]-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-phenylphenethyl propionate hydrochloride
Names
[ CAS No. ]:
1596-70-9
[ Name ]:
[R-(R*,S*)]-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-phenylphenethyl propionate hydrochloride
[Synonym ]:
D-propoxyphene
2-Butanol,4-(dimethylamino)-3-methyl-1,2-diphenyl-,propionate (ester),hydrochloride,(L)
(2R,3S)-4-Dimethylamino-3-methyl-1,2-diphenyl-2-propionyloxy-butan,Hydrochlorid
L-Propoxyphene hydrochloride
(2R,3S)-4-dimethylamino-3-methyl-1,2-diphenyl-2-propionyloxy-butane,hydrochloride
Levopropoxyphene HCl
[4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate,hydrochloride
Levopropoxyphene hydrochloride
[4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate hydrochloride
Chemical & Physical Properties
[ Boiling Point ]:
444ºC at 760mmHg
[ Molecular Formula ]:
C22H30ClNO2
[ Molecular Weight ]:
375.93200
[ Flash Point ]:
130.6ºC
[ Exact Mass ]:
375.19700
[ PSA ]:
29.54000
[ LogP ]:
5.07750
[ Vapour Pressure ]:
4.43E-08mmHg at 25°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EL3050000
- CHEMICAL NAME :
- 2-Butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-, propionate (ester), hydrochloride, (L)-
- CAS REGISTRY NUMBER :
- 1596-70-9
- LAST UPDATED :
- 199012
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C22-H29-N-O2.Cl-H
- MOLECULAR WEIGHT :
- 375.98
- WISWESSER LINE NOTATION :
- 2VOXR&1R&Y1&1N1&1 &GH -L
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 182 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,320,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 114 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 63,451,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,319,1970