4-Pyridylamidoxime

Names

[ Name ]:
4-Pyridylamidoxime

[Synonym ]:
N-Hydroxyisonicotinamidine
MFCD00125873
Pyridine-4-carboxamide oxime
N-Hydroxy-4-pyridinecarboximidamide
N-Hydroxypyridine-4-carboximidamide
Isonicotinamide oxime
4-Pyridylamidoxime
T6NJ DYZUNQ
Isonicotinamidoxime
N'-hydroxypyridine-4-carboximidamide
T6NJ DYUM&MQ
4-Pyridinecarboximidamide, N'-hydroxy-
4-Pyridinecarboximidamide, N-hydroxy-
4-Pyridylamide oxime
N-Hydroxy-isonicotinamidine

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
350.0±34.0 °C at 760 mmHg

[ Melting Point ]:
128-133 °C(lit.)

[ Molecular Formula ]:
C₆H₇N₃O

[ Molecular Weight ]:
137.139

[ Flash Point ]:
165.5±25.7 °C

[ Exact Mass ]:
137.058914

[ PSA ]:
71.50000

[ LogP ]:
-0.11

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.620

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NS1050000

CHEMICAL NAME :: Isonicotinamidoxime

CAS REGISTRY NUMBER :: 1594-57-6

LAST UPDATED :: 198609

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H7-N3-O

MOLECULAR WEIGHT :: 137.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 321 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962- Volume(issue)/page/year: 25,839,1977

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NS1050000

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A 'one-pot'synthesis of a-1, 2, 4-oxadiazolo esters from malonic diesters and amidoximes under solvent-free conditions. Du W, et al.

Tetrahedron Lett. 47(25) , 4271-4274, (2006)