N-(2,6-Dimethylphenl)-2-Piperidine Carboxamide
Names
[ CAS No. ]:
15883-20-2
[ Name ]:
N-(2,6-Dimethylphenl)-2-Piperidine Carboxamide
[Synonym ]:
N-(2',6'- Dinethylphenyl)-2-piperidinecarboxamide HCL
UNII:NF8RN1V7VM
Mepivacaine impurity B
Desbutylbupivacaine
(RS)-N-(2,6-Dimethylphenyl)piperidine-2-carboxamide,Desbutylbupivacaine
N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide
N-Desbutyl Bupivacaine
MFCD08458869
2',6'-Pipecoloxylidide
2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-
N-(2,6-Dimethylphenyl)piperidine-2-carboxamide
N-(2',6'-Dimethylphenyl)-2-piperidinecarboxamide
(RS)-N-(2,6-Dimethylphenyl)piperidine-2-carboxamide
N-(2,6-DIMETHYLPHENYL ) -PIPERIDINE-2-CARBOXYLIC AMIDE
Bupivacaine Impurity 4
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
392.3±42.0 °C at 760 mmHg
[ Melting Point ]:
114-117ºC
[ Molecular Formula ]:
C14H20N2O
[ Molecular Weight ]:
232.321
[ Flash Point ]:
149.0±28.0 °C
[ Exact Mass ]:
232.157562
[ PSA ]:
41.13000
[ LogP ]:
2.29
[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C
[ Index of Refraction ]:
1.567
[ Storage condition ]:
-20°C Freezer
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TM6076000
- CHEMICAL NAME :
- 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-
- CAS REGISTRY NUMBER :
- 15883-20-2
- BEILSTEIN REFERENCE NO. :
- 0206391
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C14-H20-N2-O
- MOLECULAR WEIGHT :
- 232.36
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974- Volume(issue)/page/year: 21,997,1994
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0155176
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301
[ Precautionary Statements ]:
Missing Phrase - N15.00950417
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
25
[ Safety Phrases ]:
45
[ RIDADR ]:
UN 2811 6.1 / PGIII
[ RTECS ]:
TM6076000
[ HS Code ]:
2933399090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933399090
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Can. J. Anaesth. 42(5 Pt 1) , 434-7, (1995)
Previous studies have reported that clonidine pretreatment causes an increase in the local anaesthetic activity of bupivacaine. This study was designed to document possible changes in the pharmacokine...
Population pharmacokinetic analysis of ropivacaine and its metabolite 2',6'-pipecoloxylidide from pooled data in neonates, infants, and children.Br. J. Anaesth. 107(3) , 409-24, (2011)
The aim was to characterize ropivacaine and 2',6'-pipecoloxylidide (PPX) pharmacokinetics and factors affecting them in paediatric anaesthesia.Population pharmacokinetics of ropivacaine and its active...
Bupivacaine kinetics during hyperthermia in rats.Can. J. Anaesth. 41(3) , 253-6, (1994)
The aim of this study was to document possible alterations of bupivacaine pharmacokinetic behaviour in rats during hyperthermia. Two groups of Wistar AF IO PS male rats (Group A = normothermic control...