GPR39 modulator 7

Names

[ Name ]:
GPR39 modulator 7

[Synonym ]:
N-(5-{[2-({[trans-4-({[(3-Cyanophenyl)sulfonyl]amino}methyl)cyclohexyl]methyl}amino)-6-(2-pyridinyl)-4-pyrimidinyl]amino}pentyl)acetamide
Acetamide, N-[5-[[2-[[[trans-4-[[[(3-cyanophenyl)sulfonyl]amino]methyl]cyclohexyl]methyl]amino]-6-(2-pyridinyl)-4-pyrimidinyl]amino]pentyl]-
N-(5-((2-((((1r,4r)-4-((3-Cyanophenylsulfonamido)methyl)cyclohexyl)methyl)amino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)pentyl)acetamide

Biological Activity

[Description]:

GPR39 modulator 7 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=20 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels; activates the orphan receptor GPR39, which signals to the Gli transcription factors and blocks signaling; a useful chemical tool for in vitro interrogation of GPR39 signaling in different cellular contexts.

[References]

References 1. Bassilana F, et al. Nat Chem Biol. 2014 May;10(5):343-9. View Related Products by Target GPR39

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₃₁H₄₀N₈O₃S

[ Molecular Weight ]:
604.766

[ Exact Mass ]:
604.294434

[ LogP ]:
2.50

[ Index of Refraction ]:
1.624

Related Compounds

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