IFN-γ Antagonist

Names

[ Name ]:
IFN-γ Antagonist

[Synonym ]:
L-Alanyl-L-tyrosyl-S-(acetamidomethyl)-L-cysteinyl-L-arginyl-L-α-aspartylglycyl-L-lysyl-L-isoleucylglycyl-L-prolyl-L-prolyl-L-lysyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-arginyl-L-lysyl-L-α- glutamyl-L-α-glutamyl-L-lysyl-L-glutaminyl-L-isoleucine
L-Isoleucine, L-alanyl-L-tyrosyl-S-[(acetylamino)methyl]-L-cysteinyl-L-arginyl-L-α-aspartylglycyl-L-lysyl-L-isoleucylglycyl-L-prolyl-L-prolyl-L-lysyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-arginy l-L-lysyl-L-α-glutamyl-L-α-glutamyl-L-lysyl-L-glutaminyl-

Biological Activity

[Description]:

IFN-γ Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI) is an antagonist of interferon γ (IFN γ). IFN-γ Antagonist 1 inhibits IFN-γ induced HLR/DR antigen expression in Colon 205 cells with an IC50 value of approximately 35 μM. IFN-γ Antagonist 1 has potential applications in immune regulation[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> IFNAR

Research Areas >> Inflammation/Immunology

[References]

[1]. Seelig GF, et al. Development of a receptor peptide antagonist to human gamma-interferon and characterization of its ligand-bound conformation using transferred nuclear Overhauser effect spectroscopy. J Biol Chem. 1995 Apr 21;270(16):9241-9.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₁₅H₁₉₄N₃₄O₃₄S

[ Molecular Weight ]:
2629.04

[ Exact Mass ]:
2627.421631

[ LogP ]:
-4.95

[ Index of Refraction ]:
1.653

Related Compounds

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