GSK2983559 free acid

Names

[ Name ]:
GSK2983559 free acid

[Synonym ]:
2-({4-(1,3-Benzothiazol-5-ylamino)-6-[(2-methyl-2-propanyl)sulfonyl]-7-quinazolinyl}oxy)ethyl dihydrogen phosphate
Ethanol, 2-[[4-(5-benzothiazolylamino)-6-[(1,1-dimethylethyl)sulfonyl]-7-quinazolinyl]oxy]-, dihydrogen phosphate (ester)

Biological Activity

[Description]:

GSK2983559 free acid (compound 3) is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1].

[Target]

RIP2[1]

[References]

[1]. Haile PA, et al. Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases. J Med Chem. 2019 Jul 25;62(14):6482-6494.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
823.6±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₃N₄O₇PS₂

[ Molecular Weight ]:
538.534

[ Flash Point ]:
451.9±37.1 °C

[ Exact Mass ]:
538.074585

[ LogP ]:
0.55

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.675

Related Compounds

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