CCT-271850

Names

[ Name ]:
CCT-271850

[Synonym ]:
N8-[(2S)-3,3-Dimethyl-2-butanyl]-N2-[2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine
compound 34h [PMID: 27055065]
Pyrido[3,4-d]pyrimidine-2,8-diamine, N2-[2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl]-N8-[(1S)-1,2,2-trimethylpropyl]-
MFCD28963915

Biological Activity

[Description]:

Mps1-IN-7 is a potent MPS1 inhibitor (IC50 of 0.020 μM) over JNK1 and JNK2 (JNK1 IC50 = 0.11 μM, JNK2 IC50=0.22 μM). Mps1-IN-7 inhibit SW620, CAL51, Miapaca-2, RMG1 cell growth with GI50 values of 0.065, 0.068, 0.25, and 0.110 μM,respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cytoskeleton >> Mps1

Signaling Pathways >> Cell Cycle/DNA Damage >> Mps1

[Target]

IC50: 0.020 μM (MSP1)[1]

[References]

[1]. Paolo Innocenti, et al. Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach. J Med Chem. 2016 Apr 28;59(8):3671-88

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
641.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₉N₇O

[ Molecular Weight ]:
431.53

[ Flash Point ]:
341.6±34.3 °C

[ Exact Mass ]:
431.243347

[ LogP ]:
3.63

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.639

Related Compounds

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