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Taxuspine B

Names

[ CAS No. ]:
157414-05-6

[ Name ]:
Taxuspine B

[Synonym ]:
(1R,2S,3E,5S,7S,8S,10R,13S)-2,7,13-Triacetoxy-10-hydroxy-8,12,15,15-tetramethyl-9-oxotricyclo[9.3.1.14,8]hexadeca-3,11-dien-5-yl (2E)-3-phenylacrylate
2-Propenoic acid, 3-phenyl-, (1R,2S,3E,5S,7S,8S,10R,13S)-2,7,13-tris(acetyloxy)-10-hydroxy-8,12,15,15-tetramethyl-9-oxotricyclo[9.3.1.14,8]hexadeca-3,11-dien-5-yl ester, (2E)-
(1R,2S,3E,5S,7S,8S,10R,13S)-2,7,13-tris(acetyloxy)-10-hydroxy-8,12,15,15-tetramethyl-9-oxotricyclo[9.3.1.14,8]hexadeca-3,11-dien-5-yl (2E)-3-phenylprop-2-enoate

Biological Activity

[Description]:

Taxuspine B is a natural product, that can be isolated from Japanese yew Taxus. Taxuspine B exhibits appreciable taxol-like activity to reduce CaCl2-induced depolymerixation of microtubules among the taxoids[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Taxuspine B 对小鼠淋巴瘤 L1210 (IC50=18 μg/mL) 和人表皮样癌 KB 细胞表现出较弱的细胞毒性，在 10 μg/mL 时抑制率分别为 42.3% 和 11.8% [1]。

[References]

[1]. Juníchi Kobayashi, et al. Taxuspines A-C, new taxoids from Japanese yew Taxus cuspidata inhibiting drug transport activity of P-glycoprotein in multidrug-resistant cells. 1994, 50(25):7401-7416.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
709.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C35H42O10

[ Molecular Weight ]:
622.70

[ Flash Point ]:
216.8±26.4 °C

[ Exact Mass ]:
622.277771

[ LogP ]:
5.14

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.573

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds