1-Propoxy-2-propanol
Names
[ CAS No. ]:
1569-01-3
[ Name ]:
1-Propoxy-2-propanol
[Synonym ]:
1-propoxypropan-2-ol
Propylene Glycol Monopropyl Ether (contains 2-Isopropoxy-1-propanol)
EINECS 216-372-4
MFCD00192420
Chemical & Physical Properties
[ Density]:
0.885 g/mL at 25 °C(lit.)
[ Boiling Point ]:
140-160 °C(lit.)
[ Melting Point ]:
-80ºC
[ Molecular Formula ]:
C6H14O2
[ Molecular Weight ]:
118.17400
[ Flash Point ]:
50 ºC
[ Exact Mass ]:
118.09900
[ PSA ]:
29.46000
[ LogP ]:
0.79380
[ Index of Refraction ]:
n20/D 1.411(lit.)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UB9351000
- CHEMICAL NAME :
- 2-Propanol, 1-propoxy-
- CAS REGISTRY NUMBER :
- 1569-01-3
- BEILSTEIN REFERENCE NO. :
- 1732636
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C6-H14-O2
- MOLECULAR WEIGHT :
- 118.20
- WISWESSER LINE NOTATION :
- QY1&1O3
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 30,126,1988
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 30,126,1988 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2504 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia
- REFERENCE :
- VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 30,126,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3550 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,3983,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2000 ppm/6H/11D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - corneal damage Behavioral - general anesthetic Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536527
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2000 ppm/6H/11D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - corneal damage Behavioral - general anesthetic Related to Chronic Data - death
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536527 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1497 No. of Facilities: 130 (estimated) No. of Industries: 7 No. of Occupations: 22 No. of Employees: 5055 (estimated) No. of Female Employees: 434 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H226-H319
[ Precautionary Statements ]:
P210-P305 + P351 + P338-P370 + P378
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
10-36/37/38
[ Safety Phrases ]:
S16-S26-S36
[ RIDADR ]:
UN 3271 3/PG 3
[ WGK Germany ]:
2
[ RTECS ]:
UB9351000
[ Packaging Group ]:
III
[ Hazard Class ]:
3.2
[ HS Code ]:
2909499000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2909499000
[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%
Articles
J. Chem. Phys. 142 , 214505, (2015)
The dielectric relaxations in six primary and secondary alkoxy alcohols with varying molecular size and different separation between -O- and hydroxyl group are studied at temperatures around glass tra...
The acute toxicity and primary irritancy of 1-propoxy-2-propanol.Vet. Hum. Toxicol. 30(2) , 126-9, (1988)
1-Propoxy-2-propanol, a widely used industrial chemical, was found to have acute peroral LD50 values in the rat of 4.92 ml/kg (males) and 2.83 ml/kg (females), with the signs of systemic toxicity bein...