1-Propoxy-2-propanol

Names

[ Name ]:
1-Propoxy-2-propanol

[Synonym ]:
1-propoxypropan-2-ol
Propylene Glycol Monopropyl Ether (contains 2-Isopropoxy-1-propanol)
EINECS 216-372-4
MFCD00192420

Chemical & Physical Properties

[ Density]:
0.885 g/mL at 25 °C(lit.)

[ Boiling Point ]:
140-160 °C(lit.)

[ Melting Point ]:
-80ºC

[ Molecular Formula ]:
C₆H₁₄O₂

[ Molecular Weight ]:
118.17400

[ Flash Point ]:
50 ºC

[ Exact Mass ]:
118.09900

[ PSA ]:
29.46000

[ LogP ]:
0.79380

[ Index of Refraction ]:
n20/D 1.411(lit.)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UB9351000

CHEMICAL NAME :: 2-Propanol, 1-propoxy-

CAS REGISTRY NUMBER :: 1569-01-3

BEILSTEIN REFERENCE NO. :: 1732636

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C6-H14-O2

MOLECULAR WEIGHT :: 118.20

WISWESSER LINE NOTATION :: QY1&1O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 30,126,1988

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 30,126,1988 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2504 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia

REFERENCE :: VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 30,126,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,3983,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2000 ppm/6H/11D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - corneal damage Behavioral - general anesthetic Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536527

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2000 ppm/6H/11D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - corneal damage Behavioral - general anesthetic Related to Chronic Data - death

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536527 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1497 No. of Facilities: 130 (estimated) No. of Industries: 7 No. of Occupations: 22 No. of Employees: 5055 (estimated) No. of Female Employees: 434 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H319

[ Precautionary Statements ]:
P210-P305 + P351 + P338-P370 + P378

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
10-36/37/38

[ Safety Phrases ]:
S16-S26-S36

[ RIDADR ]:
UN 3271 3/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
UB9351000

[ Packaging Group ]:
III

[ Hazard Class ]:
3.2

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Anomaly in dielectric relaxation dispersion of glass-forming alkoxy alcohols.

J. Chem. Phys. 142 , 214505, (2015)

The dielectric relaxations in six primary and secondary alkoxy alcohols with varying molecular size and different separation between -O- and hydroxyl group are studied at temperatures around glass tra...

The acute toxicity and primary irritancy of 1-propoxy-2-propanol.

Vet. Hum. Toxicol. 30(2) , 126-9, (1988)

1-Propoxy-2-propanol, a widely used industrial chemical, was found to have acute peroral LD50 values in the rat of 4.92 ml/kg (males) and 2.83 ml/kg (females), with the signs of systemic toxicity bein...