5,6-trans-Travoprost

Names

[ Name ]:
5,6-trans-Travoprost

[Synonym ]:
Isopropyl (5E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl}cyclopentyl]-5-heptenoate
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-, 1-methylethyl ester, (5E)-
Isopropyl (5E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate

Biological Activity

[Description]:

5,6-trans-Travoprost is the inactive isomer of Travoprost (HY-B0584), and can be used as an experimental control. Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Others >> Others

[References]

[1]. M R Hellberg, et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J Ocul Pharmacol Ther. 2001 Oct;17(5):421-32.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
584.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₃₅F₃O₆

[ Molecular Weight ]:
500.55

[ Flash Point ]:
307.5±30.1 °C

[ Exact Mass ]:
500.238586

[ LogP ]:
3.98

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.547

Related Compounds

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