CEP-751
Names
[ CAS No. ]:
156177-59-2
[ Name ]:
CEP-751
Biological Activity
[Description]:
A potent inhibitor of TrkA with IC50 of 2.9 nM, also inhibits TrkB, TrkC; shows weak inhibition for PDGFR and bFGFR, has no effect on EGF, IGF-I, insulin, ErbB receptors; exhibits anti-tumor efficacy against tumors derived from NIH3T3 cells transfected with trkA; inhibits tumor growth in MTC cell xenografts.
[References]
References 1. Camoratto AM, et al. Int J Cancer. 1997 Aug 7;72(4):673-9. 2. Dionne CA, et al. Clin Cancer Res. 1998 Aug;4(8):1887-98. 3. Strock CJ, et al. Cancer Res. 2003 Sep 1;63(17):5559-63. View Related Products by Target Trk Receptor
Chemical & Physical Properties
[ Molecular Formula ]:
C27H23N3O4
[ Molecular Weight ]:
453.4957