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Aminoethyl-SS-ethylalcohol

Names

[ CAS No. ]:
15579-01-8

[ Name ]:
Aminoethyl-SS-ethylalcohol

Biological Activity

[Description]:

Aminoethyl-SS-ethylalcohol (Compound 3) is an Alkyl-Chain-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminoethyl-SS-ethylalcohol is also a glutathione cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

Cleavable


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[References]

[1]. Zhang H, et al. Striking a Balance between Carbonate/Carbamate Linkage Bond- and Reduction-Sensitive Disulfide Bond-Bearing Linker for Tailored Controlled Release: In Situ Covalent-Albumin-Binding Gemcitabine Prodrugs Promote Bioavailability and Tumor Accumulation. J Med Chem. 2018 Jun 14;61(11):4904-4917.

[2]. Yuelog Ma, et al. HUMANIZED LEWIS-Y SPECIFIC ANTIBODY-BASED DELIVERY OF DICER SUBSTRATE siRNA (D-siRNA) AGAINST STAT3. US20130052731A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C4H11NOS2

[ Molecular Weight ]:
153.27

Related Compounds