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(3R,5S)-Fluvastatin

Names

[ CAS No. ]:
155229-75-7

[ Name ]:
(3R,5S)-Fluvastatin

Biological Activity

[Description]:

(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)
Signaling Pathways >> Autophagy >> Autophagy

[References]

[1]. Araújo FA, Rocha MA, Capettini LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24.

[2]. Makabe S, Takahashi Y, Watanabe H, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84.

[3]. Scripture CD, Pieper JA. Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81.

Chemical & Physical Properties

[ Density]:
1.23

[ Boiling Point ]:
681.8ºC at 760 mmHg

[ Molecular Formula ]:
C24H26FNO4

[ Molecular Weight ]:
433.44800

[ Flash Point ]:
366.1ºC

[ Exact Mass ]:
433.16700

[ PSA ]:
85.52000

[ LogP ]:
3.29340

Related Compounds