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CC-17369

Names

[ CAS No. ]:
1547162-46-8

[ Name ]:
CC-17369

[Synonym ]:
1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-7-hydroxy-
CC-17369
4-Amino-2-(2,6-dioxo-3-piperidinyl)-7-hydroxy-1H-isoindole-1,3(2H)-dione
2Z346T86O9
UNII:2Z346T86O9

Biological Activity

[Description]:

CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for protein by a linker to form PROTAC[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon


[References]

[1]. Hoffmann M, et al. Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother Pharmacol. 2013;71(2):489-501.

[2]. Makbul C, et al. Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability. Elife. 2020;9:e57277. Published 2020 Aug 14.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
649.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H11N3O5

[ Molecular Weight ]:
289.24

[ Flash Point ]:
346.7±31.5 °C

[ Exact Mass ]:
289.069885

[ LogP ]:
-1.97

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.725

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds