Olmesartan impurity

Names

[ Name ]:
Olmesartan impurity

Biological Activity

[Description]:

Olmesartan impurity is an Olmesartan impurity. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist has the potential for high blood pressure study[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor

Research Areas >> Metabolic Disease

[References]

[1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7.

[2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9.

Chemical & Physical Properties

[ Density]:
1.17g/cm3

[ Boiling Point ]:
724.8ºC at 760 mmHg

[ Molecular Formula ]:
C₃₃H₂₆N₄O

[ Molecular Weight ]:
494.58600

[ Flash Point ]:
392.1ºC

[ Exact Mass ]:
494.21100

[ PSA ]:
63.83000

[ LogP ]:
6.33960

[ Vapour Pressure ]:
4.74E-22mmHg at 25°C

[ Index of Refraction ]:
1.654

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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