Methyl brevifolincarboxylate

Names

[ Name ]:
Methyl brevifolincarboxylate

[Synonym ]:
methyl 7,8,9-trihydroxy-3,5-dioxo-1,2,3,5-tetrahydrocyclopenta[c]isochromene-1-carboxylate
Methyl brevifolincarboxylate
methyl 7,8,9-trihydroxy-3,5-dioxo-1,2-dihydrocyclopenta[c]isochromene-1-carboxylate

Biological Activity

[Description]:

Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate exhibits inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC50s of 27.16 μM and 33.41 μM. Anti-oxidant activity[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

[In Vitro]

Methyl brevifolincarboxylate exhibits significant DPPH radical scavenging activity with an IC50 value of 8.9 μM.

[References]

[1]. Wu QY, et al. Chromatographic fingerprint and the simultaneous determination of five bioactive components of geranium carolinianum L. water extract by high performance liquid chromatography. Int J Mol Sci. 2011;12(12):8740-8749.

[2]. Fang SH, et al. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol. 2008;116(2):333-340.

Chemical & Physical Properties

[ Density]:
1.78g/cm3

[ Boiling Point ]:
633.9ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₁₀O₈

[ Molecular Weight ]:
306.22400

[ Flash Point ]:
245.9ºC

[ Exact Mass ]:
306.03800

[ PSA ]:
134.27000

[ LogP ]:
0.75280

[ Vapour Pressure ]:
1.15E-16mmHg at 25°C

[ Index of Refraction ]:
1.717

Related Compounds

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