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ANQ 11125

Names

[ CAS No. ]:
153966-48-4

[ Name ]:
ANQ 11125

Biological Activity

[Description]:

ANQ-11125 is a potent and selective antagonist of motilin, with the pKd of 8.24. ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> GPCR/G Protein >> Motilin Receptor

[Target]

pKd: 8.24 (motilin)[1]


[References]

[1]. Depoortere I, et, al. Antagonistic properties of [Phe3,Leu13]porcine motilin. Eur J Pharmacol. 1995 Nov 24; 286(3):241-7.

[2]. Peeters TL, et, al. The motilin antagonist ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit. Biochem Biophys Res Commun. 1994 Jan 28; 198(2): 411-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C86H125N19O21

[ Molecular Weight ]:
1761.03

Related Compounds