Plevitrexed

Names

[ Name ]:
Plevitrexed

[Synonym ]:
(2S)-2-((4-(((2,7-Dimethyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)(prop-2-ynyl)amino)-2-fluorobenzoyl)amino)-4-(1H-tetrazol-5-yl)butanoic acid
Vamidex
BGC 9331
(aS)-a-[[4-[[(1,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic Acid
ZD 9331
FLUOROBENZAMIDO)-4-(1H-TETRAZOL-5-YL)BUTYRIC ACID

Biological Activity

[Description]:

Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical[1][2][3].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Thymidylate Synthase

Research Areas >> Cancer

[In Vitro]

ZD9331 inhibits the transport of [3H]-methotrexate into L1210 and W1L2 cells with a Ki of∼1 µM[3].

[References]

[1]. Tochowicz A, et al. Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem. 2013 Jul 11;56(13):5446-55.

[2]. A. Thomas, et al. A phase I/II study of plevitrexed with nutritional vitamin supplementation in gastric cancer.

[3]. Marsham PR, et al. Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. J Med Chem. 1999 Sep 23;42(19):3809-20.

Chemical & Physical Properties

[ Density]:
1.44g/cm3

[ Molecular Formula ]:
C₂₆H₂₅FN₈O₄

[ Molecular Weight ]:
532.52600

[ Exact Mass ]:
532.19800

[ PSA ]:
169.85000

[ LogP ]:
2.03860

[ Index of Refraction ]:
1.683

Related Compounds

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