Glycolithocholic acid 3-sulfate

Names

[ Name ]:
Glycolithocholic acid 3-sulfate

[Synonym ]:
Glycolithocholate 3-sulfate
Sulfolithocholylglycine
N-(3alpha-hydroxy-5beta-cholan-24-oyl)-glycine 3-sulfate
Sulfoglycolithocholate
[(3R,5R,8R,9S,10S,13R,14S,17R)-17-[(2R)-5-(carboxymethylamino)-5-oxopentan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] sulfate

Biological Activity

[Description]:

Glycolithocholic acid 3-sulfate (SLCG) is a cholic acid derivative and a metabolite of glycolithocholic acid. Glycolithocholic acid 3-sulfate inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate can be used for the research of HIV infection and gallbladder disease[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

[Target]

Microbial Metabolite

[In Vitro]

Glycolithocholic acid 3-sulfate (100 μg/mL) 可保护 MT-4 细胞免受 HIV-1 诱导的细胞病变[1]。 Glycolithocholic acid 3-sulfate (200 μg/mL) 对宿主细胞无毒性[1]。 Glycolithocholic acid 3-sulfate 抑制 HIV-1 感染的 CEM 细胞中 HIV-1 抗原的表达[1]。

[In Vivo]

Glycolithocholic acid 3-sulfate (24 μmoL/100 g；静脉注射，1 次) 诱导胆瘘的雄性 Wistar 大鼠肝内胆汁淤积，增加胆汁胆固醇分泌[2]。 Animal Model: Male Wistar rats with bile fistula[2] Dosage: 24 μmoL/100 g Administration: Intravenous injection; 24 μmoL/100 g Result: Induced intrahepatic cholestasis and increased biliary cholesterol secretion.

[References]

[1]. Baba M, et al. Selective activity of several cholic acid derivatives against human immunodeficiency virus replication in vitro. J Acquir Immune Defic Syndr (1988). 1989;2(3):264-71.

[2]. Yousef IM,et al. Lithocholate cholestasis--sulfated glycolithocholate-induced intrahepatic cholestasis in rats. Gastroenterology. 1981 Feb;80(2):233-41.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₄₂NO₇S

[ Molecular Weight ]:
512.67900

[ Exact Mass ]:
512.26800

[ PSA ]:
144.70000

[ LogP ]:
6.24400

Related Compounds

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