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Tesidolumab

Names

[ CAS No. ]:
1531594-08-7

[ Name ]:
Tesidolumab

Biological Activity

[Description]:

Tesidolumab (LFG316) is a fully-human IgG1/λ anti-C5 monoclonal antibody of 143 kDa (without glycosylation). Tesidolumab (LFG316) blocks cleavage of C5 and prevents subsequent formation of the membrane attack complex[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Complement System
Research Areas >> Inflammation/Immunology

[In Vitro]

Tesidolumab (LFG316) possesses a half-life in humans of approximately 9 days. Tesidolumab (LFG316) binds to a distinct epitope to that of eculizumab and ravulizumab, distant to Arg 885[1].

[References]

[1]. Jun-Ichi Nishimura, et al. Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria. Haematologica. 2022 Jun 1;107(6):1483-1488.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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