5-(DIMETHYLAMINO)-N-(3,4-DIMETHYL-5-ISOXAZOLYL)-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE

Names

[ Name ]:
5-(DIMETHYLAMINO)-N-(3,4-DIMETHYL-5-ISOXAZOLYL)-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE

[Synonym ]:
Tocris-1441
5-Ddins

Biological Activity

[Description]:

BMS 182874 is an orallyactive, highly selective endothelin receptor (ETA receptor) antagonist, with IC50 value of 0.150 μM, Ki of 0.055 μM. BMS 182874 reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor

[Target]

ETA:0.15 μM (IC50)

ETA:0.055 μM (Ki)

[References]

[1]. Abdullaha M, et.al. Methoxy-naphthyl-Linked N-Benzyl Pyridinium Styryls as Dual Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship. ACS Omega. 2023 May 9;8(20):17591-17608.

Chemical & Physical Properties

[ Density]:
1.332g/cm3

[ Boiling Point ]:
524.5ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₁₉N₃O₃S

[ Molecular Weight ]:
345.42

[ Flash Point ]:
271ºC

[ Exact Mass ]:
345.11500

[ PSA ]:
83.82000

[ LogP ]:
4.46520

[ Vapour Pressure ]:
4.3E-11mmHg at 25°C

[ Index of Refraction ]:
1.646

Related Compounds

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