LY 292728

Names

[ CAS No. ]:
153034-77-6

[ Name ]:
LY 292728

[Synonym ]:
9h-xanthene-4-propanoic acid,7-carboxy-3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-9-oxo

Biological Activity

[Description]:

LY 292728 is a potent leukotriene B4 (LTB4) receptor antagonist. LY 292728 binds to human neutrophils with a Ki of 0.47 nM and binds to guinea pig lung membranes with a Ki of 0.04 nM[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor
Research Areas >> Inflammation/Immunology

[References]

[1]. Sawyer JS, et al. Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3982-4.  

Chemical & Physical Properties

[ Density]:
1.376g/cm3

[ Boiling Point ]:
836.6ºC at 760 mmHg

[ Molecular Formula ]:
C34H29FO9

[ Molecular Weight ]:
600.58700

[ Flash Point ]:
459.8ºC

[ Exact Mass ]:
600.18000

[ PSA ]:
143.50000

[ LogP ]:
6.58360

[ Vapour Pressure ]:
1.07E-29mmHg at 25°C

[ Index of Refraction ]:
1.636

Related Compounds

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