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Nebadensin

Names

[ CAS No. ]:
152743-19-6

[ Name ]:
Nebadensin

[Synonym ]:
shidiaolanjiasu
Nebadensin
4H-1-Benzopyran-4-one, 5,7-dihydroxy-6,8-dimethoxy-2-(4-methoxyphenyl)-
5,7-Dihydroxy-6,8-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
5,7-Dihydroxy-6,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

Biological Activity

[Description]:

Lysionotin is a flavonoid isolated from few flower lysionotus herbs. Lysionotin efficiently inhibit α-Toxin (a pore-forming protein) expression and shows significant protection against S. aureus in vitro and in vivo. Lysionotin has the potential for the treatment of S. aureus induced pneumonia[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Target]

IC50: α-Toxin[1]


[References]

[1]. Teng Z, et al.Lysionotin attenuates Staphylococcus aureus pathogenicity by inhibiting α-toxin expression.Appl Microbiol Biotechnol. 2017 Sep;101(17):6697-6703.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
615.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H16O7

[ Molecular Weight ]:
344.315

[ Flash Point ]:
227.0±25.0 °C

[ Exact Mass ]:
344.089600

[ PSA ]:
98.36000

[ LogP ]:
1.79

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.627

Related Compounds