Cartap Hydrochloride

Names

[ Name ]:
Cartap Hydrochloride

[Synonym ]:
S,S'-[2-(Dimethylamino)-1,3-propanediyl] dicarbamothioate hydrochloride (1:1)
vegetox
UNII-IWO0R06728
kartap
Cartapp
ntd2
Cartap hydrochloride
patap
Cadan
S,S'-[2-(Dimethylamino)propane-1,3-diyl] dicarbamothioate hydrochloride (1:1)
S,S'-[2-(Dimethylamino)-1,3-propanediyl] dicarbamothioate hydrochloride
Cartap monohydrochloride
EINECS 239-309-2
Padan
Carbamothioic acid, S,S'-[2-(dimethylamino)-1,3-propanediyl] ester, hydrochloride (1:1)
S,S’-[2-(dimethylamino)-1,3-propanediyl] dicarbamothioate hydrochloride (1:1)
Carta
S,S’-(2-dimethylaminotrimethylene) bis(thiocarbamate) hydrochloride
Cardan
padan4g

Biological Activity

[Description]:

Cartap hydrochloride, an organonitrogen insecticide, can cause a marked irreversible Ca2+-dependent contracture in both isolated mouse and rabbit phrenic nerve-diaphragms. Cartap hydrochloride significantly increases the level of endogenous reactive oxygen species (ROS) in C2C12 cells[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Jiunn-Wang Liao, et al. Cartap-induced cytotoxicity in mouse C2C12 myoblast cell line and the roles of calcium ion and oxidative stress on the toxic effects. Toxicology. 2006 Feb 15;219(1-3):73-84

Chemical & Physical Properties

[ Density]:
1.42 g/cm3 (20ºC)

[ Boiling Point ]:
407.2ºC at 760 mmHg

[ Melting Point ]:
54-58 °C(lit.)

[ Molecular Formula ]:
C₇H₁₆ClN₃O₂S₂

[ Molecular Weight ]:
273.804

[ Flash Point ]:
200.1ºC

[ Exact Mass ]:
273.037231

[ PSA ]:
140.02000

[ LogP ]:
2.74300

[ Vapour Pressure ]:
7.7E-07mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FD1225000

CHEMICAL NAME :: Carbamic acid, thio-, S,S'-(2-(dimethylamino)trimethylene) ester, monohydrochloride

CAS REGISTRY NUMBER :: 15263-52-2

LAST UPDATED :: 199707

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C7-H15-N3-O2-S2.Cl-H

MOLECULAR WEIGHT :: 273.83

WISWESSER LINE NOTATION :: ZVS1Y1SVZN1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 34,935,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,78,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,132,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 17,491,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 390 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HPBIA9 Herba Polonica. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.11- 1965- Volume(issue)/page/year: 21,53,1975 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 700 mg/kg

SEX/DURATION :: female 9-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 30,776,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 300 mg/kg

SEX/DURATION :: female 8-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 30,776,1971

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H410

[ Precautionary Statements ]:
P273-P280-P501

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R21/22;R50/53

[ Safety Phrases ]:
2-36/37-60-61

[ RIDADR ]:
2771

[ WGK Germany ]:
3

[ RTECS ]:
FD1225000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2930200011

Customs

[ HS Code ]: 2930200011

[ Summary ]:
2930200011 s,s'-(2-(dimethylamino)propane-1,3-diyl) dicarbamothioate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

Articles

Effects of various insecticides on the development of the egg parasitoid Trichogramma dendrolimi (Hymenoptera: Trichogrammatidae).

J. Econ. Entomol. 94(6) , 1340-3, (2001)

The toxicity of six insecticides, acephate, methomyl, ethofenprox, cartap, chlorfluazuron, and Bacillus thuringiensis (Bt) was tested on different developmental stages of the egg parasitoid, Trichogra...

Microbial biomass and carbon mineralization in agricultural soils as affected by pesticide addition.

Bull. Environ. Contam. Toxicol. 88(4) , 538-42, (2012)

A laboratory study was conducted with four pesticides, viz. a fungicide (carbendazim), two insecticides (chlorpyrifos and cartap hydrochloride) and an herbicide (pretilachlor) applied to a sandy clay ...

Assessment of the molluscicidal activities of Tribromosalan, Cartap and Chlorothalonil against Oncomelania hupensis.

Jpn. J. Med. Sci. Biol. 45(2) , 75-80, (1992)

Molluscicidal activities of Tribromosalan, Cartap and Chlorothalonil were evaluated in the laboratory and the field against Oncomelania hupensis, the intermediate host of Schistosoma japonicum in Chin...

Related Compounds

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