CGP-53716

Names

[ Name ]:
CGP-53716

[Synonym ]:
N-[4-methyl-3-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]benzamide
N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide

Biological Activity

[Description]:

CGP 53716 is a potent protein tyrosine kinase inhibitor. CGP 53716 has selective activity of platelet-derived growth factor (PDGF) receptor. CGP 53716 can be used in the study of disease induced by abnormal cell proliferation induced by PDGF receptor activation [1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Buchdunger E, et al. Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2558-62.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₉N₅O

[ Molecular Weight ]:
381.43

[ Exact Mass ]:
381.15900

[ PSA ]:
79.80000

[ LogP ]:
4.98890

Related Compounds

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