sulfo-NHS-acetate

Names

[ Name ]:
sulfo-NHS-acetate

[Synonym ]:
Sulfo-nhs-acetate
BIM103
Sulfosuccinimidyl acetate
3-Pyrrolidinesulfonicacid,1-(acetyloxy)-2,5-dioxo
1-Acetoxy-2,5-dioxopyrrolidine-3-sulfonic acid

Biological Activity

[Description]:

Sulfo-NHS-Acetate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.8g/cm3

[ Molecular Formula ]:
C₆H₇NO₇S

[ Molecular Weight ]:
237.18700

[ Exact Mass ]:
236.99400

[ PSA ]:
126.43000

[ Index of Refraction ]:
1.583

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2925190090

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%