Cortodoxone

Names

[ CAS No. ]:
152-58-9

[ Name ]:
Cortodoxone

[Synonym ]:
11-deoxy-17-hydroxy-Corticosterone
CORTEXOLONE
17-Hydroxy-11-desoxy-corticosterone
SK&F 3050
4-Pregnene-17α,21-diol-3,20-dione
17-(1-Keto-2-hydroxyethyl)-4-androsten-17a-ol-3-one
11-Deoxycortisol
11-deoxy-Cortisol
17α,21-Dihydroxy-4-pregnene-3,20-dione
11-dioxy-cortiso
Reichstein S
17,21-Dihydroxyprogesterone
17,21-Dihydroxypregn-4-ene-3,20-dione
Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
Reichstein's substance S
11-Desoxycortisone
Cortodoxone
11-Desoxycortisol
Reichstein's "Substance S"
17-Hydroxy-11-deoxycorticosterone
4-Pregnene-17a,21-diol-3,20-dione
Cortisol, 11-deoxy-
17,21-Dihydroxy-4-pregnene-3,20-dione
11-Deoxy-17-hydroxycorticosterone
17-hydroxydesoxycorticosterone
11-dioxycortisol
EINECS 205-805-2
Corticosterone, 11-deoxy-17-hydroxy-
17,21-Dihydroxy-pregn-4-ene-3,20-dione
skf3050
MFCD00003662

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
524.5±50.0 °C at 760 mmHg

[ Melting Point ]:
205-208 °C

[ Molecular Formula ]:
C₂₁H₃₀O₄

[ Molecular Weight ]:
346.461

[ Flash Point ]:
285.1±26.6 °C

[ Exact Mass ]:
346.214417

[ PSA ]:
74.60000

[ LogP ]:
2.74

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.578

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5011500

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 17,21-dihydroxy-

CAS REGISTRY NUMBER :: 152-58-9

BEILSTEIN REFERENCE NO. :: 2511358

LAST UPDATED :: 199703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H30-O4

MOLECULAR WEIGHT :: 346.51

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 E1 FV1Q FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Human Liver

DOSE/DURATION :: 2 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 370,49,1996

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
R22;R24/25

[ Safety Phrases ]:
S24/25-S22

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ RTECS ]:
TU5011500

Precursor & DownStream

Precursor

DownStream

Articles

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

J. Med. Chem. 48 , 3269-79, (2005)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.

J. Med. Chem. 51 , 2047-56, (2008)

A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data s...