Azido-PEG1

Names

[ Name ]:
Azido-PEG1

[Synonym ]:
4-Chloro-6-[2-(diphenylmethyl)hydrazino]-5-pyrimidinamine
5-Pyrimidinamine, 4-chloro-6-[2-(diphenylmethyl)hydrazinyl]-

Biological Activity

[Description]:

Azido-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
411.7±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₆ClN₅

[ Molecular Weight ]:
325.795

[ Flash Point ]:
202.8±28.7 °C

[ Exact Mass ]:
325.109436

[ PSA ]:
69.98000

[ LogP ]:
5.39

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.698

Safety Information

[ HS Code ]:
2929909090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2929909090

[ Summary ]:
2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%