Elgemtumab

Names

[ Name ]:
Elgemtumab

Biological Activity

[Description]:

Elgemtumab(LJM716) is a fully human IgG monoclonal antibody. Elgemtumab can specifically bind to HER3, block ligand-dependent and independent HER3 signal transduction and cell proliferation, and has good anti-tumor potential[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[In Vivo]

Elgemtumab(LJM716)(i.v., 20 mg/kg,once)在 BT474 乳腺癌异种移植物的 SCID 小鼠中，可以使 pHER3 最大减少 52%，pAKT 最大减少 84 %；而在 BxPC-3 胰腺异种移植物的 SCID 小鼠中，导致 pHER3 的最大抑制为 86%，pAKT 的最大抑制为 74%[1]。 Elgemtumab(LJM716)(20 mg/kg, every other day, 35 days)在 BT474 乳腺癌异种移植物的 NSG 小鼠中，可以减缓肿瘤生长[1]。

[References]

[1]. Andrew P Garner, et al. An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer Res. 2013 Oct 1;73(19):6024-35.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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