Pramlintide

Names

[ Name ]:
Pramlintide

[Synonym ]:
Triproamylin

Biological Activity

[Description]:

Pramlintide is a polypeptide analogue of human amylin. Pramlintide is an antidiabetic, is antineoplastic in colorectal cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

Pramlintide inhibits the growth of HCT-116 and HT-29 in a dose-dependent manner, with higher efficacy against the latter (IC50s of 48.67 and 9.10 μg/mL, respectively)[1]. The addition of 5, 10, and 20 μg/mL of Pramlintide to HCT-116 and HT-29 with 5-fluorouracil, Oxaliplatin, or Irinotecan induces the antiproliferative effect synergistically[1].

[References]

[1]. Maha S Al-Keilani, et al. Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy. Clin Pharmacol. 2018 Mar 5;10:23-29.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇₁H₂₆₉N₅₁O₅₃S₂

[ Molecular Weight ]:
3949.43

[ Storage condition ]:
-20℃

Related Compounds

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