β-Estradiol 17-(β-D-glucuronide) sodium salt

Names

[ Name ]:
β-Estradiol 17-(β-D-glucuronide) sodium salt

[Synonym ]:
Hexopyranosiduronic acid, 3-hydroxyestra-1,3,5(10)-trien-17-yl, sodium salt (1:1)

Biological Activity

[Description]:

Estradiol 17-(β-D-Glucuronide) sodium, a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans[1].

[Related Catalog]:

Research Areas >> Endocrinology

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[References]

[1]. Kinbara S, et al. Improvement of estradiol-17 beta-D-glucuronide-induced cholestasis by sodium tauroursodeoxycholate therapy in rats. Scand J Gastroenterol. 1997;32(9):947-952.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₂NaO₈

[ Molecular Weight ]:
471.496

[ Exact Mass ]:
471.199493

[ PSA ]:
136.68000

[ LogP ]:
1.52570

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332-H351

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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