WST-1

Names

[ Name ]:
WST-1

[Synonym ]:
v1316
wst-1

Biological Activity

[Description]:

WST-1 is a Tetrazolium dye, widely used in the cell viability assays. WST-1 produces a water-soluble formazan product (WST-1 formazan) that occurs at the cell surface in NADPH dependent manner in viable cells[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[In Vitro]

WST-1 is used for a wide range of assays that include cell viability, proliferation, plasma membrane electron transport system, superoxide generation, superoxide dismutase, and xanthine oxidase assay[1]. A water-soluble formazan dye is produced from the reduction of WST-1 tetrazolium, of which optical density at 450 nm is measured to evaluate cell viability[1].

[References]

[1]. Kyung-Mi Joo, et al. Development and validation of UPLC method for WST-1 cell viability assay and its application to MCTT HCE™ eye irritation test for colorful substances. Toxicol In Vitro. 2019 Oct;60:412-419.

[2]. Munetaka ISHIYAMA, et al. A new sulfonated tetrazolium salt that produces a highly water-soluble formazan dye. Chem. Pharm. Bull. 1993, 41(6): 1118-1122.

Chemical & Physical Properties

[ Melting Point ]:
> 300°C (dec.)

[ Molecular Formula ]:
C₁₉H₁₁IN₅NaO₈S₂

[ Molecular Weight ]:
651.34400

[ Exact Mass ]:
650.89900

[ PSA ]:
211.57000

[ LogP ]:
4.21680

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
C

Related Compounds

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