QO IIR

Names

[ Name ]:
QO IIR

[Synonym ]:
(E)-3-(3,4-Dihydroxy-2-nitrophenyl)-1-phenylprop-2-en-1-one

Biological Activity

[Description]:

QO IIR is a reversible, tight-binding inhibitor inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 320 nM; fully reverses the reserpine-induced catalepsy in vivo, demonstrates behavioural and neurochemical effects in reserpinized rats treated with LD/CD.

[References]

References 1. Rivas E, et al. Br J Pharmacol. 1999 Apr;126(7):1667-73. 2. Pérez RA, et al. Biochem Pharmacol. 1993 May 25;45(10):1973-81. View Related Products by Target COMT

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₁NO₅

[ Molecular Weight ]:
285.25

[ Exact Mass ]:
285.063722

Related Compounds

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