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Thalidomide-5,6-F

Names

[ CAS No. ]:
1496997-41-1

[ Name ]:
Thalidomide-5,6-F

[Synonym ]:
MFCD32853274
2-(2,6-Dioxo-3-piperidinyl)-5,6-difluoro-1H-isoindole-1,3(2H)-dione
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5,6-difluoro-

Biological Activity

[Description]:

Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Liu K, et al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013;11(29):4757-4763.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
534.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H8F2N2O4

[ Molecular Weight ]:
294.21

[ Flash Point ]:
277.1±30.1 °C

[ Exact Mass ]:
294.045227

[ LogP ]:
0.55

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.609

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds