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UNC 2881

Names

[ CAS No. ]:
1493764-08-1

[ Name ]:
UNC 2881

[Synonym ]:
5-Pyrimidinecarboxamide, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-
2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[4-(1H-imidazol-1-yl)benzyl]-5-pyrimidinecarboxamide
UNC2881

Biological Activity

[Description]:

UNC2881 is a potent and specific Mer kinase inhibitor; inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. IC50 value: 22 nM [1]Target: Mer kinase inhibitorTreatment with UNC2281 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, UNC2881 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> TAM Receptor
Research Areas >> Cardiovascular Disease

[References]

[1]. Zhang W, et al. Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem. 2013 Dec 12;56(23):9693-700.


[Related Small Molecules]

Bemcentinib (R428) | Gilteritinib | BMS-777607 | TP-0903 | LDC1267 | CEP-40783 | SGI-7079 | UNC2250 | 2-D08 | Glesatinib hydrochloride | Ningetinib | NPS-1034 | R916562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C25H33N7O2

[ Molecular Weight ]:
463.575

[ Exact Mass ]:
463.269562

[ PSA ]:
116.99000

[ LogP ]:
3.03

[ Index of Refraction ]:
1.666

[ Storage condition ]:
-20℃

[ Water Solubility ]:
Insuluble (1.7E-3 g/L) (25 ºC)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ RIDADR ]:
NONH for all modes of transport

Related Compounds