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Thrombospondin-1 (1016-1023) (human, bovine, mouse)

Names

[ CAS No. ]:
149234-04-8

[ Name ]:
Thrombospondin-1 (1016-1023) (human, bovine, mouse)

[Synonym ]:
L-Lysine, N5-(diaminomethylene)-L-ornithyl-L-phenylalanyl-L-tyrosyl-L-valyl-L-valyl-L-methionyl-L-tryptophyl-
N5-(Diaminomethylene)-L-ornithyl-L-phenylalanyl-L-tyrosyl-L-valyl-L-valyl-L-methionyl-L-tryptophyl-L-lysine

Biological Activity

[Description]:

Thrombospondin-1 (1016-1023) (human, bovine, mouse), is the C-terminal end of the native sequence of Thrombospondin-1 (TSP-1), is a CD47 agonist peptide[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Inflammation/Immunology

[In Vitro]

Thrombospondin-1 (1016-1023) (human, bovine, mouse) (4N1K; 100 µg/mL; for 60 min) 处理会导致单核细胞来源的未成熟树突状细胞 (DC) 中的磷脂酰丝氨酸暴露和细胞膜完整性丧失。当肽浓度为 25-200 µg/mL 时，膜联蛋白 V+ 细胞的数量会随着肽浓度的增加而增加。Thrombospondin-1 (1016-1023) (human, bovine, mouse) 可降低 DC 中的线粒体膜电位和片段化 DNA[2]。

[References]

[1]. Chih-Jian Lih, et al. Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes. Genes Dev. 2006 Aug 1;20(15):2082-95.  

[2]. U Johansson, et al. CD47 ligation induces a rapid caspase-independent apoptosis-like cell death in human monocytes and dendritic cells. Scand J Immunol. 2004 Jan;59(1):40-9.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C56H81N13O10S

[ Molecular Weight ]:
1128.388

[ Exact Mass ]:
1127.594971

[ LogP ]:
3.79

[ Index of Refraction ]:
1.647

Related Compounds