Ac-YVAD-pNA

Names

[ Name ]:
Ac-YVAD-pNA

[Synonym ]:
Ac-Tyr-Val-Ala-Asp-PNA
IL-1beta Converting Enzyme (ICE) Colorimetric Substrate
Ac-Tyr-Val-Ala-Asp-paranitroanilide
L-α-Asparagine, N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-
N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-α-asparagine
Caspase-1 Substrate IV,Colorimetric
Ac-YVAD-pNA

Biological Activity

[Description]:

Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Caspase

Research Areas >> Inflammation/Immunology

[Target]

Caspase-1

[References]

[1]. Pereira NA, et al. Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity. Biochem Biophys Res Commun. 2008 Dec 19;377(3):873-7.

[2]. Xin W, Wang Q, et al. A new mechanism of inhibition of IL-1β secretion by celastrol through the NLRP3 inflammasome pathway. Eur J Pharmacol. 2017 Nov 5;814:240-247.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1108.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₉H₃₆N₆O₁₀

[ Molecular Weight ]:
628.63

[ Flash Point ]:
624.5±34.3 °C

[ Exact Mass ]:
628.249268

[ PSA ]:
248.85000

[ LogP ]:
2.61

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.605

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.