3,4'-Dihydroxyflavone

Names

[ Name ]:
3,4'-Dihydroxyflavone

[Synonym ]:
3-Hydroxy-2-(4-hydroxyphenyl)chromone
4'-Hydroxyflavonol
3-hydroxy-2-(4-hydroxy-phenyl)-chromen-4-one
3,4'-dihydroxyfavone
3-Hydroxy-2-(4-hydroxy-phenyl)-chromen-4-on
3,4'-dihydroxyfalvone
3,4'-Dihydroxyflavone

Biological Activity

[Description]:

3,4'-Dihydroxyflavone (3,4'-DHF) is an oral active flavonoid with antiviral activity against Influenza A virus[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

[In Vivo]

3,4'-Dihydroxyflavone (3,4'-DHF; PO, 1 mg/kg per 30 μL, daily, 5 days) significantly decreases virus titers and pathological changes in the lung and reduced body weight loss and death[1]. Animal Model: 3,4'-Dihydroxyflavone (3,4'-DHF; PO, 1 mg/kg per 30 μL, daily, 5 days) significantly decreases virus titers and pathological changes in the lung and reduced body weight loss and death[1]. Dosage: 1 mg/kg per 30 μL. Administration: Oral administration daily for 5 days. Result: Significantly decreased virus titers and pathological changes in the lung and reduced body weight loss and death.

[References]

[1]. Hossain MK, et al. Antiviral activity of 3,4'-dihydroxyflavone on influenza a virus. J Microbiol. 2014 Jun;52(6):521-6.

Chemical & Physical Properties

[ Density]:
1.472g/cm3

[ Boiling Point ]:
452.5ºC at 760mmHg

[ Melting Point ]:
275-276ºC

[ Molecular Formula ]:
C₁₅H₁₀O₄

[ Molecular Weight ]:
254.24

[ Flash Point ]:
175.7ºC

[ Exact Mass ]:
254.05800

[ PSA ]:
70.67000

[ LogP ]:
2.87120

[ Vapour Pressure ]:
5.61E-09mmHg at 25°C

[ Index of Refraction ]:
1.712

MSDS

Click to get detail MSDS

Safety Information

[ HS Code ]:
2914501900

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%