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Fmoc-Lys(Pal-Glu-OtBu)-OH

Names

[ CAS No. ]:
1491158-62-3

[ Name ]:
Fmoc-Lys(Pal-Glu-OtBu)-OH

[Synonym ]:
MFCD27952849
N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N6-[N-(1-oxohexadecyl)-L-gamma-glutamyl]-L-lysine 1'-(1,1-dimethylethyl) ester
Fmoc-Lys(Pal-Glu-Otbu)-OH

Biological Activity

[Description]:

Fmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys(Pal-Glu-OtBu)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
944.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C46H69N3O8

[ Molecular Weight ]:
792.055

[ Flash Point ]:
524.8±34.3 °C

[ Exact Mass ]:
791.508484

[ LogP ]:
11.05

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.530

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds